Equipoise Explained: Benefits, Dosage, and Effects for Bodybuilders

What is Equipoise?

Boldenone Undecylenate

Equipoise, also known as Boldenone, is an oil-based injectable anabolic steroid that features the Undecylenate ester for prolonged release and half-life. Originally developed for veterinary use, bodybuilders and athletes have favored it as a less androgenic alternative to Testosterone with lower estrogenic activity. Derived from Testosterone, Equipoise maintains its anabolic potency while exhibiting reduced androgenic effects. Although some liken it to Nandrolone (Deca Durabolin), the comparison is flawed as Nandrolone belongs to a different class of compounds and possesses distinct properties. Nonetheless, many users interchange Nandrolone and Equipoise in their cycles, considering them viable substitutes for one another.

Equipoise facts

Here are a few interesting facts about this compound: Equipoise was developed in 1949, even before Dianabol (Methandrostenolone), making it technically the first synthetic derivative of Testosterone. Dianabol is essentially Equipoise (Boldenone) with a methyl group attached to make it orally bioavailable. This methyl group changes the properties enough to classify it as a different steroid called Methandrostenolone (Dianabol). If you compare the chemical structures of Equipoise and Dianabol, they’re almost identical, except for the methyl group on Dianabol. This shows that these two steroids are essentially the same.

History of Equipoise

Equipoise, initially developed in 1949, wasn’t released until the 1960s, marketed as Parenabol by Ciba. During the interim, Ciba experimented with different esters to enhance its properties. Ultimately, Equipoise was released with the Undecylenate ester, becoming Boldenone Undecylenate.

Parenabol underwent clinical trials in the late 1960s and early 1970s for treating conditions causing weight loss and wasting, as well as osteoporosis. However, it saw limited use and was discontinued by the late 1970s.

Squibb later acquired the patents and reintroduced Boldenone as Equipoise, primarily for veterinary use, especially in horses. Equipoise is known for promoting lean mass and stimulating appetite more than other steroids. Despite changes in manufacturing and marketing, Equipoise remains available in the American and international markets under various generic and brand names.

Functions and properties of Equipoise

As mentioned earlier, Equipoise is a synthetic derivative of Testosterone with modifications at carbon 1 and carbon 2, where double bonds are added between these carbon atoms. This alteration reduces Equipoise’s affinity for interacting with the aromatase enzyme, responsible for converting androgens into Estrogen, resulting in lower Estrogenic activity compared to Testosterone. Equipoise is essentially Boldenone with the Undecylenate ester attached to it. Undecylenate, chemically known as Undecylenoic acid, is bonded to the 17-beta hydroxyl group on the Boldenone structure, forming an ester linkage.

Adding this ester enhances the hormone’s release rate and half-life, prolonging its activity. Once Boldenone Undecylenate enters the bloodstream, enzymes gradually break the bond between the ester and the hormone. This process varies in duration, leading to the removal of the ester from the hormone. Consequently, pure Boldenone becomes available to exert its effects in the body. This enzymatic process of ester removal accounts for the slower release rates. With the Undecylenate ester attached, Boldenone’s half-life extends to approximately 14 days, resulting in a slower release and activity compared to Boldenone without this ester.

Equipoise is similar to Dianabol

Equipoise and Dianabol share identical structures, differing only in the attachment to their 17-beta hydroxyl group: Undecylenate ester in Equipoise, methyl group in Dianabol. Despite structural similarity, their effects differ markedly, suggesting that the addition of a methyl group alters properties beyond liver resistance.

Properties of Equipoise

Equipoise, derived from Testosterone, shares its anabolic strength (rating 100) and aromatizable nature, but with reduced aromatization due to double-bond modifications. This lowers Estrogenic activity, lessening water retention, though not eliminating it entirely. While Equipoise still converts to Estrogen, it does so to a lesser extent than Testosterone, mitigating estrogenic side effects. However, caution is warranted, especially at higher doses, as increased aromatization may occur.

Equipoise boasts a lower androgenic rating compared to Testosterone, appealing to those sensitive to androgenic effects. Expect solid lean muscle gains with minimal water retention, making it suitable for bulking or lean mass cycles. Equipoise can serve as a viable alternative to Nandrolone in stacks.

Equipoise side effects

Equipoise exhibits lower estrogenic activity compared to Testosterone, with about half the aromatization rate. However, it still surpasses Nandrolone in estrogenic effects. Dosages above 200-400mg weekly may increase estrogenic side effects, necessitating anti-estrogens or aromatase inhibitors to manage water retention, bloating, and potential gynecomastia.

While Equipoise has milder androgenic effects than Testosterone, androgenic side effects are still possible. It interacts with the 5-alpha reductase enzyme, converting into Dihydroboldenone (DHB) instead of DHT, albeit at a lower rate. Androgenic effects may include oily skin, acne, increased body/facial hair growth, and male pattern baldness predisposition.

Equipoise isn’t hepatotoxic and poses similar cardiovascular risks and Testosterone suppression as other anabolic steroids.

Estrogen side effects of Equipoise

Boldenone aromatizes to estrogen to a lesser extent, but high estrogen levels can lead to gynecomastia, water retention, and high blood pressure. Most men can manage related side effects with moderate doses, but higher doses may require additional attention.

To counteract estrogenic side effects, an anti-estrogen medication may be necessary. While not always needed, having one on hand is advisable. Options include Selective Estrogen Receptor Modulators (SERMs) like Nolvadex (Tamoxifen Citrate) and Aromatase Inhibitors (AIs) like Arimidex (Anastrozole). AIs are more effective as they inhibit the aromatase process, reducing total serum estrogen levels, albeit potentially impacting cholesterol. SERMs bind to estrogen receptors without inhibiting aromatase, with the added benefit of potentially improving cholesterol levels. SERMs are preferred initially due to potential cholesterol concerns, with AIs considered if necessary.

Masculinising side effects of Equipoise

Equipoise can cause androgenic effects like acne, hair loss, and body hair growth, though its reduced androgenicity lessens these risks. Genetic predisposition plays a significant role.

Androgenic side effects stem from Boldenone’s metabolism by the 5-alpha reductase enzyme, yielding dihydroboldenone, a potent androgen. However, its overall activity is low in humans. Unlike DHT, 5-alpha reductase inhibitors like Finasteride have minimal impact on Equipoise’s androgenic nature.

Women using Equipoise may experience virilization symptoms such as body hair growth and deepening of the voice, but the steroid’s low androgenicity makes this less likely. However, its slow-acting nature may pose challenges in controlling blood levels, prompting consideration of alternative steroids. Individual sensitivity determines outcomes; discontinuation upon symptom onset is crucial to prevent irreversible effects.

Cardiovascular side effects of Equipoise

Equipoise typically imposes less cardiovascular strain compared to many oral steroids. It can impact cholesterol ratios by suppressing HDL levels, but usually to a manageable extent for healthy adults. Introducing an aromatase inhibitor (AI) to manage estrogenic effects may worsen lipid profiles, so cholesterol management is crucial.

Regular monitoring of cholesterol levels is recommended for Equipoise users, emphasizing a cholesterol-friendly lifestyle with a diet rich in omega fatty acids and cardiovascular exercise. Pre-supplementation assessment of cholesterol health is essential for safe use.

Equipoise and testosterone inhibition

Equipoise suppresses natural testosterone production, necessitating exogenous testosterone supplementation to prevent low testosterone levels. Post-cycle, natural testosterone production resumes, but a PCT plan is recommended to expedite recovery. Recovery time varies, but a well-planned PCT can aid in restoring testosterone levels more efficiently.

It’s important to note that natural testosterone recovery assumes no prior low testosterone levels and minimal damage to the HPTA. For those using Equipoise, a PCT plan typically begins approximately two weeks after the last injection. Some may opt to start with HCG followed by SERM therapy, while others may end Equipoise use early in the cycle to commence PCT sooner.

Dosages for Equipoise

Medical guidelines for Equipoise dosages are unavailable as it’s not approved for human use. In bodybuilding, beginner doses range from 300-500mg weekly, while intermediate users typically take 500-700mg weekly. Exceeding this range is rare, especially when used with other compounds.

For females, Equipoise’s lower androgenic effects make it suitable at 50-75mg weekly. However, its 14-day half-life may lead to slow elimination, necessitating prompt discontinuation if virilization signs appear.

To maintain stable levels, split weekly doses into two administrations spaced evenly (e.g., 500mg weekly split into 250mg on Monday and Thursday).

Stacks and Cycles with Equipoise

Equipoise cycles are typically geared towards mass gaining, often combined with Testosterone to match its longer half-life. Beginner cycles may include Testosterone Enanthate (or Cypionate) at 300-500mg per week alongside Equipoise at 400mg per week for 14 weeks. Intermediate cycles may add an oral compound like Dianabol (25mg/day) for the first 4 weeks, with Testosterone reduced to 100mg per week and Equipoise at 400-600mg per week for 12 weeks.

Advanced cycles usually maintain Equipoise dosages below 600mg per week, with Testosterone at TRT doses (100mg/week) and an additional compound like Trenbolone Enanthate (400mg/week) for 12 weeks.

Equipoise Prices and availability

Equipoise enjoys moderate popularity and usage among athletes and bodybuilders, making it a staple product for most sources or vendors. However, it’s important to note that there are currently no pharmaceutical-grade Equipoise products meant for human use. As a result, individuals seeking Equipoise typically turn to the black market, where only veterinary and Underground Laboratory (UGL) grades are available.

Equipoise comes in various forms, concentrations, dosages, and vial sizes, offering a wide array of options compared to other anabolic steroids. Common vial sizes include 10ml, 50ml, 100ml, 250ml, and even 500ml, with concentrations usually at 200mg/ml. However, some UGLs produce higher concentrations, such as 250mg/ml and beyond.

Prices for Equipoise vary depending on the source and quality. On the upper end, a single 10ml vial containing 200mg/ml of underground quality Equipoise can cost between $150 and $170. On the lower end, prices range from $60 to $100 for the same product. Veterinary Equipoise is also available, typically priced between $17 and $20 per 1ml glass ampoule containing 50mg/ml, with lower-priced options ranging from $12 to $15 per ampoule.

Conclusion

Equipoise (Boldenone Undecylenate) – FAQ for Bodybuilders

1. What is Equipoise used for in bodybuilding?

Equipoise (Boldenone Undecylenate) is primarily used to promote lean muscle gains, endurance, and strength. It increases protein synthesis and enhances red blood cell production, improving oxygen delivery to muscles. Bodybuilders often use it in bulking and cutting cycles due to its mild anabolic nature and low water retention.

2. How long does it take for Equipoise to work?

Equipoise is a slow-acting steroid due to its long undecylenate ester. Noticeable effects, such as strength gains and improved vascularity, typically appear after 4-6 weeks of consistent use. Most users run it for 12-16 weeks to maximize results.

3. What is the recommended Equipoise dosage for bodybuilding?

• Beginner: 300-500mg per week
• Intermediate: 500-700mg per week
• Advanced: 700-900mg per week
• Women: 50-100mg per week (due to androgenic side effects)
  Most users inject it once or twice a week to maintain stable blood levels.

4. Can Equipoise be used for cutting?

Yes! While commonly seen as a bulking steroid, Equipoise can be used in a cutting cycle due to its ability to preserve lean muscle mass while reducing body fat. It works well alongside Trenbolone, Winstrol, or Masteron for a dry, hard look.

5. Does Equipoise cause water retention?

No, Equipoise has low estrogenic activity, meaning it does not cause significant water retention or bloating. This makes it a great alternative to steroids like Testosterone or Deca-Durabolin, which can cause puffiness.

6. How does Equipoise compare to Testosterone?

Feature	Equipoise	Testosterone
Muscle Gains	Moderate	High
Strength Increase	Moderate	High
Water Retention	Low	Moderate
Aromatization	Low	High
Endurance Boost	High	Moderate
Androgenic Effects	Low	High
Detection Time	Up to 5 months	3-4 weeks

Equipoise is less androgenic, making it a good option for those sensitive to hair loss and acne. However, it is also less powerful for raw muscle gains compared to Testosterone.

7. Does Equipoise suppress natural testosterone production?

Yes, like all anabolic steroids, Equipoise suppresses natural testosterone production. The extent of suppression depends on dosage and cycle length, but most users require Post Cycle Therapy (PCT) with Clomid and/or Nolvadex after their cycle.

8. How long does Equipoise stay in your system?

Equipoise has a very long detection time due to its undecylenate ester. It can be detected in drug tests for up to 5 months after the last injection, making it a poor choice for tested athletes.

9. Can women use Equipoise?

Women can use Equipoise, but they should keep doses low (50-100mg per week) to minimize the risk of virilization (deep voice, facial hair growth, clitoral enlargement, etc.).

10. What are the side effects of Equipoise?

Equipoise has mild side effects compared to stronger steroids like Trenbolone, but risks include:

• Testosterone suppression (requires PCT)
• Increased red blood cell count (thicker blood, potential cardiovascular risks)
• Mild estrogen conversion (can cause bloating at high doses)
• Androgenic effects (hair loss, acne, aggression)
• Long detection time (not ideal for tested athletes)

11. Can Equipoise be stacked with other steroids?

Yes! Popular Equipoise stacks include:

• For Bulking: Equipoise + Testosterone + Dianabol
• For Cutting: Equipoise + Winstrol + Masteron
• For Lean Gains: Equipoise + Anavar + Low-dose Testosterone

12. What PCT is needed after an Equipoise cycle?

A proper PCT (Post Cycle Therapy) should start 2-3 weeks after the last injection and typically includes:

• Clomid: 50mg/day for 4 weeks
• Nolvadex: 20-40mg/day for 4 weeks
  This helps restore natural testosterone production and prevent post-cycle crashes.

13. Is Equipoise legal?

Equipoise is a veterinary steroid and is not approved for human use in many countries. It is illegal without a prescription in places like the UK, USA, Canada, and Australia. Bodybuilders often obtain it through the black market or underground labs.

14. What makes Equipoise unique compared to other steroids?

• Steady, lean muscle gains without bloating
• Enhances vascularity and endurance
• Long-acting with fewer injections needed
• Mild androgenic side effects compared to Trenbolone or Testosterone
• One of the best steroids for increasing red blood cell count

15. Should I use Equipoise if I’m a beginner?

Equipoise is a good choice for beginners because it has moderate anabolic effects, low water retention, and mild side effects. However, a beginner should always stack it with Testosterone to prevent testosterone suppression issues.

References

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1. Adverse Effects on Reproductive Functions: A study titled “Adverse effects of the anabolic steroid, boldenone undecylenate, on reproductive functions of male rabbits” found that administration of Boldenone Undecylenate led to a significant reduction in serum testosterone levels, seminal volume, sperm motility, and sperm count in male rabbits. https://link.springer.com/article/10.1007/s11064-022-03827-2
2. Hepatorenal Impairment: Research published in “Frontiers in Pharmacology” under the title “Boldenone Undecylenate-Mediated Hepatorenal Impairment by Induction of Oxidative Stress, Inflammation, and Apoptosis in Male Rats: The Modulatory Effect of Vitamin C” demonstrated that Boldenone Undecylenate can cause significant liver and kidney damage through oxidative stress and inflammation in male rats. Co-administration of Vitamin C was found to mitigate these adverse effects. https://pmc.ncbi.nlm.nih.gov/articles/PMC8111012/
3. Behavioral and Neurochemical Changes: The article “The Behavioral and Neurochemical Changes Induced by Boldenone and/or Tramadol Administration in Rats” highlighted that rats treated with Boldenone exhibited impaired memory, cognitive functions, and reduced motor activity, suggesting potential neurotoxic effects. https://link.springer.com/article/10.1007/s11064-022-03827-2
4. Impact on Growth Performance and Carcass Traits: A study titled “Effects of boldenone undecylenate on growth performance, maintenance behaviour, reproductive hormones and carcass traits of growing rabbits” found that while Boldenone Undecylenate improved growth performance and feed efficiency in rabbits, it also led to a significant decrease in serum testosterone levels and testicular size. https://journals.pan.pl/Content/105373/PDF/02.pdf
5. Regulatory and Health Risks: The U.S. Anti-Doping Agency (USADA) article “5 Things Athletes Should Know About Boldenone” emphasizes that Boldenone is not approved for human use, is classified as a probable human carcinogen, and is associated with significant reproductive harm in males, including decreased testosterone production and fertility issues. https://www.usada.org/spirit-of-sport/5-thing-athlete-know-boldenone/